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Its expression is elevated in COPD lung tissue and can be activated via three pathways: CS-induced ROS activating the PI3K-AKT pathway, macrophage TCA cycle disruption leading to succinate accumulation, and the PTGES-AKT pathway (83, 84)

Sodium-glucose cotransporter 2 inhibitors and risk of hyperkalemia in people with type 2 diabetes: A meta-analysis of individual participant data from randomized, controlled trials

In contrast, the least number of astrocytes was seen in Group 5 (Fig